Hyperoside benefit and information

Hyperoside is a flavone found in certain herbs that has potent antioxidant activity.

Hyperoside as antioxidant
Hyperoside prevents oxidative damage induced by hydrogen peroxide in lung fibroblast cells via an antioxidant effect.
Biochim Biophys Acta. 2008. Department of Biochemistry, School of Medicine, Institute of Medical Science, Cheju National University, Jeju-si, Korea.
We elucidated the cytoprotective effects of hyperoside (quercetin-3-O-galactoside) against hydrogen peroxide (H2O2)-induced cell damage. We found that hyperoside scavenged the intracellular reactive oxygen species. It was found to inhibit H2O2-induced apoptosis in Chinese hamster lung fibroblast (V79-4) cells, as shown by decreased apoptotic nuclear fragmentation, decreased sub-G(1) cell population, and decreased DNA fragmentation. In addition, hyperoside pretreatment inhibited the H2O2-induced activation of caspase-3 measured in terms of levels of cleaved caspase-3. Hyperoside prevented H2O2-induced lipid peroxidation as well as protein carbonyl. In addition, hyperoside prevented the H2O2-induced cellular DNA damage, which was established by comet tail, and phospho histone H2A.X expression. Furthermore, hyperoside increased the catalase and glutathione peroxidase activities. Conversely, the catalase inhibitor abolished the cytoprotective effect of hyperoside from H2O2-induced cell damage. In conclusion, hyperoside was shown to possess cytoprotective properties against oxidative stress by scavenging intracellular radical oxygen species and enhancing antioxidant enzyme activity.

Study of quality control on Cuscuta chinensis and C. australia
Zhong Yao Cai. 2007. Shandong Institute of TCM, Jinan, China.
To study the estimate method of Cuscuta chinensis and Cuscuta australia. HPLC was used to determine the contents of four kinds of flavones of Cuscuta chinensis and Cuscuta australia growing on different hosts. Cuscuta chinensis and Cuscuta australia growing on different hosts both had hyperoside, quercetin, kaempferol and isorhamnetin. The content range of hyperoside was 2.7 to 6.5 mg/g and was higher than other flavones. The content ranges of Quercetin, kaempferol and isorhamnetin were 0.02 to 0.17 mg/g, 0.001 to 0.21 mg/g and 0.001 to 0.077 mg/g, respectively. The contents of hyperoside and quercetin are higher in Cuscuta chinensis than in Cuscuta australia. The contents of kaempferol and isorhamnetin are lower in Cuscuta chinensis than in Cuscuta australia. The hosts influence flavones content of Cuscuta chinensis and Cuscuta australia.

Chemical constituents of Hypericum adenotrichum Spach, an endemic Turkish species.
Nat Prod Res. 2009; Cirak C, Ivanauskas L, Radusiene J. Faculty of Agriculture, Department of Agronomy, University of Ondokuz Mayis, Samsun, Turkey. The present study was conducted out to determine hyperforin, hypericin, pseudohypericin, chlorogenic acid, rutin, hyperoside, quercitrin, quercetin, kaempferol, apigenin-7-O-glucoside and amentoflavone contents of Hypericum adenotrichum, an endemic plant species to Turkey. The aerial parts representing a total of 30 individuals were collected at full flowering, dried at room temperature and assayed for secondary metabolite concentrations by HPLC. All of the chemicals were detected at various levels except for hyperforin. This is the first report on polar chemistry of this endemic species.